For direct reversal of alkylation events, a DNA methyltransferase or DNA glycosylase detects and removes the alkyl group. Excision repair can be specific or nonspecific. In base excision repair, DNA …

Deficiencies in DNA repair enzymes are occasionally caused by a newly arising somatic mutation in a DNA repair gene, but are much more frequently caused by epigenetic alterations that reduce or …

Jan 24, 2024 · The review addresses key questions, including the major types of DNA damage, common DNA repair mechanisms, the availability of reliable databases for DNA damage and associated …

Jul 30, 2025 · DNA repair enzymes are enzymes that recognize and correct physical damage in DNA, caused by exposure to radiation, UV light or reactive oxygen species. The correction of DNA damage …

In another type of repair mechanism, nucleotide excision repair, enzymes replace incorrect bases by making a cut on both the 3' and 5' ends of the incorrect base (Figure 3 4 7 3).

Specific repair enzymes recognize the mispaired nucleotide and excise part of the strand that contains it; the excised region is then resynthesized. If the mismatch remains uncorrected, it may lead to more …

Oct 22, 2025 · Cells respond to the risk of accumulated DNA damage and loss of genome integrity by utilizing cogent DNA repair enzymes.

4 days ago · It plays an important role in nuclear architecture, DNA damage repair and replication, regulation of transcription and more. Because SUMO is involved in many essential cellular functions …

DNA repair enzymes are able to recognize and correct these unnatural bases. However, an uncorrected uracil base may be misread as a thymine during subsequent DNA replication and generate a C→T …

Systems of response to DNA damage that reduce the yield of mutations and chromosomal aberrations in damaged cells are collectively known as DNA repair. Repair enzymes recognize and remove DNA …